During sample preparation, the embryos’ DNA is multiplied many times over and then “sequenced”, where the DNA sequence of all 23 pairs of human chromosomes is read. The information about the number of sequences read in this way is then compared by software to a control sample, which always has the correct number of copies of all chromosomes. During the preparation of the sample, the DNA of the embryos is multiplied many times and subsequently sequenced. Thus, the DNA sequence of all 23 pairs of human chromosomes is read.
The information about the number of sequences read in this way is then compared by software with a control sample that always has the correct number of copies of all chromosomes. In this way, we can detect whether certain sequences are overrepresented or missing in the embryo genome. This allows us to detect numerical aberrations in all human chromosomes and select the euploid embryos with the highest implantation potential for transfer. We can thus detect numerical variations in all human chromosomes and select embryos for transfer to the uterus that are not affected by chromosomal mutations during development.
