IVF treatment

It includes a wide range of methods that involve in vitro fertilization. We perform IVF with either your own or donor gametes, depending on the couple’s options.

IVF treatment

It includes a wide range of methods that involve in vitro fertilization. We perform IVF with either your own or donor gametes, depending on the couple’s options.

You're only 3 visits away from having a baby

See how IVF treatment works.

IVF success rate

99% of couples conceive within 4 IVF cycles with us.
Approximately 7 out of 10 couples only need one IVF cycle to achieve pregnancy.

However, the success rate of IVF is very individual. Many factors play a role – your overall health, age, but also your mental well-being.

Approximate price

At our clinic, you can take advantage of various pricing packages, which include different examinations, genetic testing, and methods that increase the likelihood of conception.

The final price offer is always based on the recommendations of our experts and IVF specialists.

 

Schedule a non-binding consultation with us

And take the first step on your baby journey. The doctor will discuss with you everything you are interested in and suggest the next steps.

How IVF treatment works

1. Initial consultation

The initial consultation is the gateway to IVF treatment and lasts approximately 120 minutes.

After booking through the contact form, our English-speaking coordinator will reach out to you and discuss everything you’re interested in. The appointment date does not need to be based on your menstrual cycle; you can come anytime. For the examination, you don’t need to undergo any tests in advance. However, if you have previous test results, you are welcome to bring them

We recommend that both of you come for the consultation.

More about the initial consultation

At Repromeda, we don’t believe in a one-size-fits-all approach. We believe that every couple is unique, which is why examinations are designed on an individual basis.

In women, we mainly focus on an ultrasound of the pelvis minor, hormone testing (femme test) and genetic testing.

With men, a spermogram is essential, which will enable us to suggest the next course of action, as well as genetic tests.

More about female examination

More about male examination

 

Each IVF cycle involves hormonal stimulation, which causes a higher number of eggs to mature in the woman’s ovaries than in a natural cycle.

The stimulation starts on day 2 or 3 of the menstrual cycle and lasts for a total of 10 to 12 days. The application of stimulation drugs is not a complicated process. The nurse will help you with the first dose, and you can easily manage the next one at home.

More about stimulation

EGG RETRIEVAL
We retrieve eggs using a very thin needle, which, with its significantly smaller tip diameter, is more gentle in penetrating the tissues and minimizes the risk of complications. The procedure is performed on an empty stomach and under general anaesthesia, which usually lasts no longer than 10 minutes.

After the procedure, you take a nap for a while and about an hour later you can go home with your escort.

The eggs are then fertilized on the same day and become embryos.

SPERM RETRIEVAL
Sperm is retrieved by masturbating into a sterile container after two to three days of sexual abstinence.
If you have difficulty obtaining a sample in the collection room, you can go to the retrieval room with your partner. You can also bring sperm from your hotel by prior arrangement.

More about retrieval

EGG FERTILIZATION
The embryologist evaluates the quality of the eggs and fertilizes each of them with one sperm.

Fertilization is performed using active micromanipulation methods (ICSI, PISCI), which significantly increase the embryo formation success rate.

CULTIVATION
After fertilization, we monitor the embryos and make sure they develop properly.

The embryo is cultured for 5 to 6 days to the blastocyst stage. The best embryo care is provided by the MIRI Time-Lapse Incubator.

More about egg fertilisation and cultivation

Cryopreservation, or the freezing of embryos, allows embryos to be stored for future use.

Frozen embryos can be stored for several decades, after which they are thawed and then transferred to the uterus.

After a failed IVF process or if you wish to have another pregnancy, you do not have to undergo the egg and sperm retrieval process again.

We use a state-of-the-art technique called vitrification to freeze embryos.

During this process, the embryos are rapidly cooled to a final temperature of -196 °C within seconds.

More about cryopreservation

The embryo is transferred through a thin cannula through the cervix into the uterus.

The transfer is usually completely painless and you and your partner can enjoy this moment, which might result in a new life.

More about embryo transfer

After the transfer, enjoy some peace and comfort and take the medication recommended by your doctors. If you do not get your period within 14 days of the embryo transfer, you can take a pregnancy test at home.
We will contact you after 14 days to discuss the next steps.

More information

Methods increasing IVF success

We offer several supportive methods that will most likely shorten your baby journey.

Examination of oxidative stress in the semen

Oxidative stress affects the quality and functionality of sperm and causes damage to their DNA. To detect oxidative stress, we use the fastest and most accurate test, MIOXSYS. This test enhances the accuracy of male infertility diagnosis.

BlastGen

A cultivation medium containing a growth hormone, meaning the embryo not only develops better, but also communicates with the uterine lining. It increases the chances of successful embryo transfer in utero.

Glue

The transfer of an embryo into the uterus is one of the most crucial steps in IVF treatment.

BeREADY

The test is intended for all women who, during treatment with assisted reproduction methods, have obtained a small number of embryos or experience repeated embryo implantation failures.

EndomeTRIO

An examination that includes three tests from one sample of the uterine lining. A detailed examination of the uterine environment and determining the optimal moment for embryo transfer can be a very important step in identifying the cause of infertility.

Schedule a non-binding consultation with us

And take the first step on your baby journey. The doctor will discuss with you everything you are interested in and suggest the next steps.

Most frequently asked question

In order to undergo IVF, a woman needs the signature of her partner, who does not have to be her legal husband. At the same time, the woman is not obliged to name the man as the father of the child after the birth.

By law, a woman can undergo assisted reproduction methods up to the age of 49.

A consultation with our doctor is the first step to successful treatment. During the consultation, the doctor will discuss with you your family and personal history, the course of all the examinations you have already undergone, and the procedure for the examinations and treatment you have yet to undergo. The doctor will also inform you about prices and reimbursement options from your health insurance company. Both you and your partner should attend the consultation.

One third of cases involve the male infertility factor, the female factor plays a role in a third of cases, and the last third is due to the combined infertility factor.

Specifically, we can say that in men it is mostly a question of poor spermiogram parameters, especially a low number and poor motility or morphology (shape) of the man’s sperm.

Ovulation disorders (egg maturation and release), low egg quality, endometriosis, fallopian tube obstruction, ovarian and fallopian tube adhesions are often detected in women.

Both genetic partners may also have some genetic variations that will not allow the development of the embryo and lead to infertility or repeated miscarriages.

An unexpected connection of science, holistic medicine, and empathy

We seek the right connections to lead you to your desired goal.

years
0

we’ve been here for you

children
0

have been born thanks to us

families
0

with a rare disease that we’ve helped

We are here for those who want more than just hope

We draw from our extensive experience and understand that each story is unique and deserves understanding and an individual approach.

Ostrava, Brno

MUDr. Lenka Hromadová

Chief Medical Officer and Head of IVF

lhromadova@repromeda.cz

Brno

MUDr. Martin Maděrka, Ph.D.

IVF specialist, physician

mmaderka@repromeda.cz

Brno

MUDr. Alena Filková

IVF specialist, doctor

afilkova@repromeda.cz

Brno

MUDr. Zuzana Felsingerová

IVF specialist, doctor

zfelsingerova@repromeda.cz

Ostrava

MUDr. Veronika Pasnišin

IVF specialist, doctor

vpasnisin@repromeda.cz

Brno

MUDr. Ilga Grochová

Senior Clinical Geneticist

igrochova@repromeda.cz

We have already helped bring 6 000 children into the world

Schedule a non-binding consultation with us

And take the first step on your baby journey. The doctor will discuss with you everything you are interested in and suggest the next steps.

Brno, Studentská 812/6, Czech Republic

Your questions will be answered Mon-Fri, 7am-6pm.

Emergency +420 602 592 842
Ostrava, Dr. Slabihoudka 6232/11, Czech Republic

Your questions will be answered Mon-Fri, 7am-3pm.

Emergency +420 606 029 983
Brno, Studentská 812/6, Czech Republic

Your questions will be answered Mon-Fri, 7am-6pm.

Emergency +420 602 592 842

View on map

Ostrava, Dr. Slabihoudka 6232/11, Czech Republic

Your questions will be answered Mon-Fri, 7am-3pm.

Emergency +420 606 029 983

View on map

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1. Initial consultation

The initial consultation is the gateway to the entire IVF treatment. During the 120-minute session, the doctor will discuss your family and personal medical history, and go through all the examinations you have already had. Based on this information, we will suggest the next steps. You will also learn about the approximate costs.

During the consultation, you will have the opportunity to ask any questions you may have, so we recommend coming with your partner. You don’t have to worry about being overwhelmed with technical terms; the doctor will explain everything to you clearly and understandably.

Throughout your treatment, a single “strategic doctor” will oversee your care, whom you can turn to with all your requirements, wishes, and questions. However, certain specific procedures might be performed by other equally experienced doctors. Our daily coordinators will also be available to guide you throughout the treatment process.

 

8. After the transfer

After the transfer, enjoy some peace and comfort and take the medication recommended by your doctors. In 14 days, take a pregnancy test from your morning urine. We will call you the same day, ask you about the test results, and we’ll agree on the next steps together.

Most frequently asked questions

Why can’t I take a pregnancy test until 14 days after the transfer?
During the course of IVF treatment, you take a number of drugs that can skew the result towards either a false positive or a false negative. By taking the test after 14 days, you will save yourself the unnecessary stress that could arise from false results.

Yet another control line. What should I do now?
Unfortunately, sometimes things don’t go the way we imagine and good news doesn’t come the moment we long for it the most. Don’t worry, you’re not alone. Unfortunately, even IVF treatment is not 100% successful. The IVF success rate varies depending on various factors such as your age, health and mental state. Do what you feel is right. Scream, cry, be silent, talk about it. Give vent to all your feelings. But don’t blame yourself. If you’d like to talk to a psychologist or our staff about this, we’re happy to help.

It was my first IVF failure; should I change my treatment?
With the first or second IVF failure, nothing happens. You don’t have to change anything. But if you’re wondering what else you can do to make sure you get two lines on your pregnancy test next time, we have a few tips for you. Try the beREADY endometrial receptivity test to find out your exact implantation window and determine the ideal time for your next transfer. You can also try the EndomeTRIO test, which, like the beREADY test, determines the implantation window. In addition, however, it also analyses the balance of bacteria in the endometrium and detects bacteria causing chronic inflammation.

Try the beREADY endometrial receptivity test to find out your exact implantation window and determine the ideal time for your next transfer. You can also try the EndomeTRIO test, which, like the beREADY test, determines the implantation window. In addition, however, it also analyses the balance of bacteria in the endometrium and detects bacteria causing chronic inflammation.

Do you believe in a holistic approach? So do we. Alternative medicine may not be what will always guarantee motherhood. However, it is a suitable complement to the methods of Western medicine and can really improve your health significantly.

More about alternative methods

We’ve failed repeatedly, so what now?

Your doctor may offer you the option of treatment using donated reproductive cells. We know that this decision takes time and that you will need to think about it carefully. Take your time. Everything will come when the time is right.

7. Embryo transfer

Transferring the embryo into the uterus is one of the most important steps in IVF treatment. In simple terms, it can be described as the transfer of the embryo through a thin cannula through the cervix into the uterus. The procedure is short, usually painless and is performed in the transfer room against a backdrop of relaxing music. During the transfer, you can watch a video recording of the transfer of the selected embryo and your partner can also be present during the procedure.

Embryos are ideally introduced into the uterus at the blastocyst stage. This is the 5th-6th day after the eggs have been fertilized by sperm. One option is to perform a ‘fresh transfer’; the other option is to freeze these embryos and transfer them in the next cycle (cryoembryo transfer – CET). It is the second option that we prefer at Repromeda.

Acupuncture is a suitable complement before and after the transfer. Before the transfer, you will be pleasantly attuned and your pelvic area will be relaxed, making it easier to insert the embryo. After the transfer, acupuncture is used to stimulate the circulation of blood to the uterus, which promotes nutrition and facilitates the proper development of the embryo. In addition, you will find it nice and relaxing.

What if the embryo attachment repeatedly fails?

It may happen that, despite a series of tests showing that nothing is preventing the embryo from attaching, it repeatedly fails to attach. The problem may be caused by a uterine lining that may not be sufficiently prepared for the transfer. The beReady or EndomeTRIO test can help you with this.

  • Based on an analysis of a uterine swab sample, the beREADY test determines your individual implantation window and thus the optimal time for the transfer of the embryo.
  • The EndomeTRIO test performs three tests simultaneously from a single sample of the uterine mucosa. In addition to determining the implantation window, it also analyses the bacterial balance of the endometrium and detects bacteria causing chronic inflammation.
  • A special culture medium called EmbryoGlue can help increase the chances of embryo nesting and subsequent pregnancy. This medium is formulated to mimic the conditions in a woman’s uterus while acting as a “glue”. EmbryoGlue contains all the nutrients needed for optimal embryo development and facilitates attachment to the uterine wall during transfer.

Most frequently asked questions

Why do you prefer cryoembryo transfer or CET in Repromeda?
The main reason is the higher treatment success rate. Why is that? The timing of the transfer to the woman’s next natural cycle, which is no longer burdened by hormonal stimulation (necessary for egg retrieval), increases the success rate. In the following cycles, we are usually able to ensure that the uterine lining is better prepared to receive the embryo. Another reason is the use of preimplantation genetic testing of embryos, which we now perform on most of our patients. In this case, CET is the only option for time reasons. During the delayed transfer, we examine the embryos in our genetic laboratory. In the following cycle, we transfer the most promising embryos.

Is embryo transfer painful?
For most women, this is a painless outpatient procedure. In some women, the cervix may be narrowed because of a developmental defect of the uterus or as a result of inflammation or surgery. In this case, the transfer may be slightly uncomfortable.

Why do you transfer only one embryo during embryo transfer at Repromeda?
Because we know that transferring two or more embryos does not increase the likelihood of pregnancy; it only increases the likelihood of multiple pregnancy. By transferring one embryo, we prevent multiple pregnancies, which pose a risk to both the woman and the children. The final decision on the number of embryos to be transferred is made by the couple in consultation with their doctor. However, we are very happy that the average number of transferred embryos in our clinic is 1.0. Our goal is not only to get you pregnant, but also to see a healthy baby in your arms. This is the only way we ourselves can be satisfied with our work.

Can I have twins after a single embryo transfer?
With a single embryo transfer, multiple pregnancies can only occur in cases of identical twins resulting from the division of the original single transferred embryo.

How likely am I to get pregnant?
The probability of pregnancy after the transfer of one PGT-tested embryo is up to 58%. In most cycles, however, more viable embryos are obtained. Approximately 7 out of 10 couples only need one IVF cycle to achieve pregnancy. During 4 IVF cycles 99% of couples get pregnant.

6. Cryopreservation

Cryopreservation, or the freezing of embryos, allows embryos to be stored for future use. Frozen embryos can be stored for several decades, after which they are thawed and then transferred to the uterus.

These embryos can be used after a failed transfer or if you are considering siblings in a few years. The current cryopreservation technique used in all modern workplaces is vitrification. During this process, the embryos are rapidly cooled to a final temperature of -196 °C in a few seconds, at which the cells are then stored.

We were among the first in the Czech Republic to introduce an open vitrification system in 2020. Thanks to this technique, the thawing success rate after vitrification is significantly higher and we can benefit from all the advantages of cryoembryo transfer (CET).

Most frequently asked questions

Are thawed embryos really just as good as fresh ones? Don’t we have to worry about them being damaged somehow?
Unlike the slow freezing method previously used, vitrification does not produce any ice crystals that could damage the cells. In addition, the cells are stored in special media that protect them from external factors. Even after thawing, the embryos are in excellent condition.

5. Egg fertilization and cultivation

Once we have the reproductive cells, we move to the embryology lab. This is where artificial insemination takes place. The embryologist assesses the quality of the eggs and then fertilizes each egg with one sperm. Fertilization is nowadays performed as standard using active micromanipulation methods (ICSI, PICSI), which significantly increase the embryo formation success rate.

We offer our clients a SpermPacket (for fertilization) containing a suitable combination of methods. This package includes ICSI or PICSI and optimal sperm selection, which is performed in two ways – MACS or a Zymot chip.

The method chosen to select the optimal sperm is based on previous laboratory tests, patient needs and current spermiogram parameters. The MACS method removes defective sperm with fragmented DNA from the ejaculate sample. The Zymot chip method gently sorts out the sperm with the highest motility and viability.

Embryo cultivation

After the egg has been fertilized with sperm, our embryologists monitor your embryos and make sure they develop properly. The embryo is cultured for 5 to 6 days to the blastocyst stage. We offer our clients the use of state-of-the-art MIRI Time-Lapse Incubators. These incubators ensure the best care for the embryos, providing a separate space for cultivation while continuously recording their development via a built-in camera. Since there is no need to remove them from the incubator for microscopic examination, there is no variation in the parameters of the culture conditions.

In cycles where preimplantation genetic testing (PGT), is planned, on the 5th – 6th day of development a few cells are taken from the embryo and this sample is tested in the genetic laboratory. Meanwhile, the embryos are vitrified (frozen).

Most frequently asked questions

What is classical or conventional IVF and why is it so rarely used these days?
This is a method in which eggs and sperm are placed in a “test tube” and we wait to see if spontaneous fertilization occurs without further intervention by an embryologist. However, this original method has a relatively low success rate and has been more or less replaced by the ICSI and PICSI methods.

What does the ICSI method involve?
The ICSI method is the most commonly used micromanipulation technique, in which embryologists actively transfer one sperm into each egg.

For whom is the PICSI method suitable and how exactly does it work?
The PICSI method is suitable for you if the proportion of eggs fertilized by ICSI has been low in previous cycles, if the embryos have not developed as well as they should or if there has been a miscarriage. The main role in the PICSI method is played by hyaluronan, which is an important natural component of the egg envelope. The head of a mature sperm carries a specific receptor that allows it to bind to hyaluronan. With the PICSI method, the embryologist selects for micromanipulation fertilization those sperm that show a positive binding to the hyaluronan gel.

4. Egg and sperm retrieval

Egg retrieval

After the end of hormonal stimulation comes the egg retrieval process, or puncture. It is performed on an empty stomach and under general anaesthesia and usually takes no longer than 10 minutes.

The contents of the follicles are retrieved by a doctor during an ultrasound scan using a puncture needle. For egg retrieval, we use a very thin needle, which, with its significantly smaller tip diameter, is more gentle in penetrating the tissues and thus minimizes the risk of complications.

Embryologists then search for eggs in the follicular fluid, which are fertilized the same day and become embryos.

After retrieval, you take a nap and rest for a while. You can also have a cup of tea and a bite to eat. Just one hour after the procedure, you can go home with your escort and return to your normal activities. We do not recommend driving the day after anaesthesia.

Most frequently asked questions

When and how are eggs retrieved?
The exact retrieval date is selected by the doctor following ultrasound examinations. Ovitrelle must be applied 36 hours before the puncture. Ovitrelle is a laboratory-produced hormone that is injected into a fold of skin in the lower abdomen. No need to worry about forgetting – we’ll send you a text message to let you know when the time is right.

What regimen do I need to follow before egg retrieval?
Don’t smoke or eat or drink anything from midnight before the collection. Then come to our clinic on the morning of the puncture.

What are the advantages of using a thin needle?
The Kitazato needle we use for the puncture has a tip diameter of just 0.912 mm (as opposed to the 1.149 mm needle commonly used). Using this needle is safer and less painful for patients. The treatment is also more comfortable as you need less analgesics and anaesthetics. Laser treatment of the needle tip ensures safer access to the follicle and less resistance from the surrounding tissue.

Sperm retrieval

Sperm is retrieved by masturbating into a sterile container after two to three days of sexual abstinence. Longer abstinence is not desirable, as it might not yield the expected result.

If you find it difficult to collect your sperm, you can go to the retrieval room with your partner. Alternatively, you can bring sperm from home or your hotel (in a container issued by the clinic). However, you have to bring it within one hour and hand it in in person.

3. Hormonal stimulation

Hormonal stimulation of the woman causes a higher number of eggs to mature in the ovaries than in a natural cycle. This is done by injecting drugs into the abdomen. The application of the medication is simple and painless.

We use only modern drugs for stimulation, which do not harm the body and increase the success rate of the whole treatment.

The stimulation starts on day 2 or 3 of the menstrual cycle and lasts for a total of 10 to 12 days. The application of stimulation drugs is not a complicated process. The nurse will help you with the first dose, and you can easily manage the next one at home.

During the stimulation, you will have regular check-ups where the doctor will use ultrasound and blood tests to check that everything is going well. You can have the ultrasound examinations at your local gynaecologist or at our clinic.

For many years we have been using high-quality Gonal F for hormonal stimulation, which is applied in the form of a pen and is popular for being easy to apply and highly effective.

See how to apply the medication:

Most frequently asked questions

Does hormonal stimulation harm the body?
The greatest hormonal load on a woman’s body occurs during pregnancy. With the hormonal stimulation associated with IVF treatment, hormone levels reach only a fraction of these values. If the stimulation of a woman is conducted correctly, it does not harm the body in any way.

What is ovarian hyperstimulation syndrome (OHSS)?
OHSS is the term used to describe the overreaction of the ovaries to hormonal stimulation. This condition is manifested by pain in the lower abdomen, which is caused by enlargement of the ovaries and the formation of free fluid in the abdominal cavity. Feelings of nausea or vomiting and diarrhoea may also occur. Regular and careful monitoring of the entire stimulation process prevents the development of OHSS.

How often does ovarian hyperstimulation syndrome (OHSS) occur?
With the development of modern stimulants, the risk of ovarian overstimulation syndrome (OHSS) has decreased significantly. Now these cases occur in fractions of a percent.

Are stimulation and hormone injections painful?
Pen injections are injected into the subcutaneous tissue (like insulin) and are not painful. Towards the end of the stimulation, you may feel pressure in your lower abdomen, similar to the sensation before menstruation.

Why do supplementary payments for stimulants vary so much?
In addition to recombinant preparations, which are produced in the laboratory, there are also preparations of urinary origin, which are obtained from the urine of menopausal women.
These are highly purified drugs, but they do not guarantee the quality of stimulation with the reliability and accuracy that we want to offer at our clinic. Although the additional cost of urinary preparations is an order of magnitude lower, no clinical study or our experience has yet convinced us to recommend urinary preparations as a first choice.

Which day is the first day of the cycle?
This is the first day of menstruation, i.e. heavy menstrual bleeding. Light bleeding is not considered the beginning of a cycle. If you start bleeding in the evening after 8 p.m., then the next day is considered the first day of menstruation.

Why do I have to go for check-ups during stimulation?
Your body’s response to stimulation can be individual – depending on your age, weight, egg supply and type of stimulant. That is why we monitor everything closely during the process. At check-ups, the doctor checks the ovary response with ultrasound scans and, if necessary, takes blood samples to check hormone levels.