Are you facing repeated failed embryo transfers or early miscarriages? Even if your embryos—whether your own or donated—appear healthy, your immune system could be affecting implantation. A simple blood test analyzing KIR genes may help uncover the reason.
What Are KIR Genes?
KIR genes control the behavior of natural killer (NK) cells, key immune cells found in the uterus. These cells influence whether your body accepts the embryo and allows it to grow.Every woman has a specific KIR gene profile that affects how active these cells are.
Embryos carry HLA-C antigens from the egg and sperm providers.
If the mother’s KIR profile and the embryo’s HLA-C antigens are incompatible, the immune system may respond negatively—preventing implantation or disrupting early pregnancy development.
Who Is KIR Gene Testing For?
This test is for any woman undergoing embryo transfer—whether using her own or donated eggs. It helps us understand how her immune system might respond to the embryo.
We recommend KIR gene testing if you:
- have had multiple failed embryo transfers,
- have experienced repeated miscarriages,
- had complications in previous pregnancies (e.g. preeclampsia, slow fetal growth),
- underwent unsuccessful IVF with donor eggs.
It can also be helpful if you want to reduce the risk of immunological mismatch and tailor treatment to your individual needs.
How Does the Test Work?
The process is simple and non-invasive. During a consultation, your doctor will review your medical background and treatment options. Then we collect a small blood sample to analyze your KIR gene profile.
If results suggest a potential immune response, we follow up by testing HLA-C antigens from both partners (or donors). Based on these insights, your doctor will recommend a personalized treatment plan.
Testing is performed in-house at Repromeda’s state-of-the-art genetic laboratory. Results are typically available within 5 weeks.
What This Test Can Help Us Do:
- Develop a personalized treatment strategy,
- Select a genetically compatible egg or sperm donor,
- Increase the chance your uterus will accept the embryo and support its development.
If you’re curious about KIR gene testing or wondering if it’s right for you, get in touch with us. We’ll explain everything clearly and help you choose the best next steps—designed specifically for your needs.
